(+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa.

(R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.

RA-839 is a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. RA-839 also suppresses LPS-induced iNOS and nitric oxide expression in macrophages.

Eriodictyol, a flavonoid isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with anti-inflammatory and antioxidant activities, may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance and be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness in Atopic dermatitis.

Brusatol is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 < 1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. < 50 nM in A549 cells), including NRF2.

NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ.

Farrerol is a natural product isolated and purified from the leaves of Rhododendron dauricum L.

Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM.

Danshensu, a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and antiangiogenesis effects.

Mangiferin is the predominant constituent of extracts of the mango plant Mangifera Indica L. with potential antidiabetic activity.

RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 by binding KEAP1 and inhibits the proinflammatory transcription factor NF-κB.

ML-385 is a selective inhibitor of NRF2 via binding to Neh1 DNA binding domain with IC50 of 1.9 µM.

4-Octyl itaconate is the endogenous metabolite of itaconate with anti-inflammatory activity. It can decrease cytokine production and protect against lipopolysaccharide-induced lethality in vivo.